The persistent asthma is related to a major accumulation of plaque in the arteries that lead to the brain

Los adults with persistent asthma pueden tener un major riesgo de sufrir un ataque al corazón o un ictus due to the excessive accumulation of plaque in las arterias carótidas, según un estudio publicado este miercoles en ´Journal of the American Heart Association´, una revista de acceso abierto y revisada …



Los adults with persistent asthma pueden tener un major riesgo de sufrir un ataque al corazón o un ictus due to the excessive accumulation of plaque in las arterias carótidas, según un estudio publicado este miercoles en ´Journal of the American Heart Association´, una revista de acceso abierto y revisada por expertos de la Asociación Americana del Corazón.

The people who participated in the study had more plaque accumulation in the carotid arteries, the large arteries located in the left and right sides of the neck that carry blood to the brain, compared to people without asthma.

Asthma is a respiratory disease that causes inflammation of the respiratory tract of a person (often due to allergic reactions), which makes breathing difficult. Se sabe que chronic inflammation over time contributes to the accumulation of plaques in the arteries, lo que se conoce como atherosclerosis, y se associa a un major riesgo de ruptura de las plaques, lo que unchechena un attack al corazón o un cerebral stroke.

Muchos médicos y pacientes no se dan cuenta de que la inflammación asmática de las vías respiratoryas puede afectare a las arteries, por lo que que para las personas con persistentasma con abordar los factorses de riesgo de la enfermedad cardiovascular puede ser rémonte útil. The presence and load of the carotid artery plaque is a strong predictor of future cardiovascular events“, commented the principal author of the study, Matthew C. Tattersall, assistant professor in the Department of Medicine of the University of Wisconsin in Madison (United States).



Before this analysis, the researchers used the data of the participants enrolled in the Multi-Ethnic Study of Atherosclerosis (‘MESA’) before examining the possible association between asthma and the plaque of the carotid artery.

The ´MESA´ is a research study of almost 7,000 adults that started in the year 2000 and that is still participating in six places in the United States: Baltimore, Chicago, New York, the county of Los Ángeles (California), el condado de Forsyth (Carolina del Norte) and St. Paul (Minnesota). At the moment of registration, all participants in the MESA were free of cardiovascular diseases.

The investigators revised the health data of 5,029 adults, with an average age of 61 years, who presented initial risk factors of cardiovascular disease and those who had carotide echocardiogram data. The group of participants is diverse: 26 percent of adults self-identified as Afro-American, 23 percent as Hispanic and 12 percent as Chinese. In addition, more than half of the group (53%) were women.

The participants in the cohort of this analysis were classified as persistent asthmatics, intermittent asthmatics or non-asthmatics. The subgroup with persistent asthma, defined as the one that uses daily control medications before controlling the symptoms of asthma, was formed by 109 participants; the subgroup with intermittent asthma, defined as a history of asthma but that does not use daily medications before controlling symptoms of asthma, was formed by 388 participants; y el resto de participantes no tenía asma.

At the beginning of the study, todos los participants se sometieron a una ecografía de las arteria carótidas izquierda y derecha before identifying any plaque in the carotid artery. The total score of the plaque defined the number of plaques in the walls of both carotid arteries. También se midieron los niveles en sangre de los inflamatoryo biomarkers interleucin-6 (IL-6) y protina C reactiva (PCR) at the beginning of the study.

The analysis revealed that the carotid plaque was present in 67 percent of participants with persistent asthma and in 49.5 percent of those with intermittent asthma. Those who had persistent asthma had una media de two carotídeas plaques, and those who had intermittent asthma alrededor de una carotídea plaque. Además, la placa carotídea estaba presente en el 50.5 por ciento de los participants sin asthma, con una media de una placa carotídea.

Tras adjustar la eda, el sexo, la race, el peso, otras condiciones de salud, el uso de medicamentos precedados y el tabaquismo, los participantes con persistentasma had almost twice the probability of tener plaques en las arteria carótidas than los que no they had asthma.

Compared to participants without asthma, those who had persistent asthma had higher levels of inflammatory biomarkers. The researchers discovered that IL-6 accounting and PCR in the analysis completely adjusted did not reduce the association between persistent asthma and carotid artery plaque.

Este análisis nos indica que el major riesgo de placas carotídeas entre las persona con persistentasma probabilita esté afectado por multiple factors. Los participants que padecen persistent asthma tenien nivels elevados de inflammato en la sangre, aunque su asma fuera tratada con medicación, lo que pone de manifiesto las caracteristics inflamatorias del asthma. We know that the highest levels of inflammation lead to negative effects in the cardiovascular system” Tattersall said.

In 2019, the American Heart Association published guidelines for the primary prevention of cardiovascular diseases that included various inflammatory disorders, such as arthritis and lupus, as risk factors for cardiovascular disease.

The most important message from our findings is that the most significant forms of asthma are associated with more cardiovascular diseases and cardiovascular events. Addressing cardiovascular risk factors through lifestyle and behavior adjustments can be a powerful preventive tool for patients with the most serious forms of asthma“, tattersall said.

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